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Multiple Myeloma Hub spotlight: CD38 as a therapeutic target for MM

By Jennifer Reilly

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Apr 18, 2025

Learning objective: After reading this article, learners will be able to state the role of CD38-targeted therapies in the treatment of MM.


Test your knowledge! Take our quick quiz before and after you read this article to find out if you improved your knowledge. Results help us to improve content and continually provide open-access education.

Question 1 of 1

Which of the following is NOT an example of a mechanism that anti-CD38 mAbs induce on malignant cells for the treatment of multiple myeloma?

A

B

C

D

Multiple Myeloma Hub spotlight: CD38 as a therapeutic target for MM

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CD38 is a transmembrane glycoprotein that is highly expressed on malignant plasma cells, making it a key therapeutic target for MM. Anti-CD38 mAbs, isatuximab and daratumumab act to target CD38 on MM cells, leading to cell death.

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As a result of this content, I commit to reviewing the latest data and clinical updates for CD38-directed therapies for the treatment of multiple myeloma.

This educational resource is independently supported by Sanofi. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

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